IndraLab

Statements

USP37 deubiquitinates MYC. 17 / 18
1 | 2 15
reach
"USP37 positively regulates the Warburg effect in lung cancer by deubiquitinating c-Myc [108] ."
35031261
reach
"Lastly, USP37 deubiquitinates and stabilizes the proto-oncogene c-Myc and the oncogenic fusion PLZF-RARA, suggesting that inhibition of USP37 DUB activity could have therapeutic potential XREF_BIBR, XREF_BIBR."
30858488
reach
"An early study showed that USP28 deubiquitinates c-Myc via interacting with Fbw7alpha whereas a recent study reveals that USP37 deubiquitinates c-Myc independently of Fbw7 and c-Myc phosphorylation."
26697836
reach
"Importantly, USP37 had been confirmed to accelerate keloid fibroblast proliferation and collagen production by mediating the deubiquitination and stabilization of c-Myc , suggesting that USP37 played positive role in keloid formation."
40038378
reach
"While the role of ubiquitin-specific peptidase 37 (USP37) in lung cancer, where it mediates the deubiquitination and stabilization of c-myc, has been well-documented, its involvement in DLBCL remains unexplored."
39722070
reach
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity dependent manner."
25284584
reach
"The data show that USP37 may be a potential therapeutic target for DLBCL, and that it may enhance the course of the disease by deubiquitinating c-myc via direct interactions with c-myc."
39722070
reach
"USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer."
25284584
reach
"The previously reported deubiquiting enzyme USP37 can directly bind to and deubiquitinate c-Myc, thereby stabilizing c-Myc ( Pan et al., 2015 )."
34102342
reach
"Pan et al. reported that high levels of USP37 gene expression in lung cancer promoted cell viability as well as the Warburg effect via deubiquitination and stabilization of pluripotent factor c-Myc protein [21]."
30482232
trips
"USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer."
25284584
trips
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity-dependent manner."
25284584
reach
"Recent evidence has revealed that c-Myc can be deubiquitylated and regulated by USP28, USP36 and USP37."
29263902
reach
"It is worth mentioning that USP37 also deubiquitinates and stabilizes c-Myc to affect proliferation in cancer cells82."
34405018
reach
"USP37 promotes diffuse large B-cell lymphoma progression by deubiquitinating and stabilizing c-myc."
39722070
reach
"Additionally, USP37 has been reported to promote the Warburg effect in cancer cells and the proliferation of lung cancer cells by deubiquitinating Myc [68]."
39146353
reach
"For example, Usp9x binds and stabilizes Mcl1, and Usp37 interacts with and deubiquitinates Myc [97,98] ."
26459133