IndraLab

Statements


USP37 deubiquitinates MYC. 10 / 10
1 | 2 7

reach
"Lastly, USP37 deubiquitinates and stabilizes the proto-oncogene c-Myc and the oncogenic fusion PLZF-RARA, suggesting that inhibition of USP37 DUB activity could have therapeutic potential XREF_BIBR, XREF_BIBR."

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"It is worth mentioning that USP37 also deubiquitinates and stabilizes c-Myc to affect proliferation in cancer cells82."

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"Recent evidence has revealed that c-Myc can be deubiquitylated and regulated by USP28, USP36 and USP37."

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"USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer."

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"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity dependent manner."

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"An early study showed that USP28 deubiquitinates c-Myc via interacting with Fbw7alpha whereas a recent study reveals that USP37 deubiquitinates c-Myc independently of Fbw7 and c-Myc phosphorylation."

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"Pan et al. reported that high levels of USP37 gene expression in lung cancer promoted cell viability as well as the Warburg effect via deubiquitination and stabilization of pluripotent factor c-Myc protein [21]."

trips
"USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer."

trips
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity-dependent manner."