IndraLab

Statements

COPS5 activates CUL. 4 / 4
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"Reconciling this paradox, we show here that Csn5 catalysed cullin (Cul) deneddylation and Ubp12 mediated deubiquitination cooperate in maintaining the stability of labile substrate adapters, thus facilitating CRL function."
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"In turn, the protected Jab1 activity can prevent the degradation of Cullin RING E3 ligases by the Ub/Ub like dependent degradation pathways."
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"These observations present a paradox : If CSN5 causes Cullin deneddylation via its metalloprotease activity, why does CSN promote CRL activity?"
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"Thus, both a 2-hour MLN treatment and a long-term CSN5 siRNA knockdown attenuate the degradation of SIAH-1, while a 2-hour MLN treatment applied to CSN5 siRNA-knockdown cells does not further add to t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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