IndraLab

Statements

COPS5 activates CUL. 10 / 10
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"Recently, CSN6 has been speculated to play a role in structural integrity of the CSN complex and cullin deneddylation catalyzed by CSN5 [19] ."
30180991
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"Thus, both a 2-hour MLN treatment and a long-term CSN5 siRNA knockdown attenuate the degradation of SIAH-1, while a 2-hour MLN treatment applied to CSN5 siRNA-knockdown cells does not further add to t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A notable role of JAB1 is modulating the activity of cullin-RING ubiquitin ligases (CRLs)."
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"CSN5-mediated cullin deneddylation can regulate SCF complex disassembly, which is required for FRQ ubiquitination [62,63]."
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"CSN6 has been speculated to play a role in structural integrity of the CSN complex and cullin deneddylation catalyzed by CSN5 [19] ."
30180991
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"Knockout of COP9-signalosome subunit 5 (CSN5) suppresses the deneddylation of cullin and leads to cardiac hypertrophy and heart failure [24,25] ."
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"Cullin deneddylation is specifically mediated by CSN subunit CSN5 that is active only when incorporated into CSN [ 22 , 47 ]."
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"These observations present a paradox : If CSN5 causes Cullin deneddylation via its metalloprotease activity, why does CSN promote CRL activity?"
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"In turn, the protected Jab1 activity can prevent the degradation of Cullin RING E3 ligases by the Ub/Ub like dependent degradation pathways."
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"Reconciling this paradox, we show here that Csn5 catalysed cullin (Cul) deneddylation and Ubp12 mediated deubiquitination cooperate in maintaining the stability of labile substrate adapters, thus facilitating CRL function."
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