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OTUD3 inhibits Neoplasms. 2 / 2
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"These experiments collectively confirmed that OTUD3 can suppress the growth and proliferation of tumor cells.Moreover, to corroborate these findings, we conducted CCK8 cell proliferation assays on HeLa-WT, OTUD3-GFP, OTUD3-KO, OTUD3-KO cells with exogenous expression of wild-type OTUD3 (OTUD3-KO+OTUD3-Myc), and OTUD3-KO cells with exogenous expression of catalytically inactive OTUD3 (OTUD3-KO+OTUD3-C76A-Myc)."
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eidos
"OTU domain-containing protein 3 ( OTUD3 ) , as a deubiquitinase ( DUB ) belonging to the ovarian tumor protease ( OTU ) family , has been reported to suppress tumor via OTUD3-PTEN signaling axis ."
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