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KEAP1 inhibits USP15. 2 / 2

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"Moreover, depletion of Kelch-like ECH-associated protein 1 (Keap1) diminished the regulatory effect of USP15 inhibition on Nrf2 activation."

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"Given that Nrf2 exerts gene regulation in the oxidative stress response, it is quite reasonable that oxidative stress could repress the Keap1 mediated proteasomal degradation of Nrf2 by suppressing US[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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Statements

KEAP1 inhibits USP15. 2 / 2

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