IndraLab

Statements

BAP1 inhibits Malignant Mesothelioma. 7 / 7
| 7
reach
"BAP1 suppresses MM cell proliferation."
26011428
reach
"In effusions with mesotheliomatous cells or atypical mesothelial cells of uncertain significance, negative BAP1 IHC strongly supports a diagnosis of MM."
28994508
reach
"In this study, we observed BAP1 expression loss in five of eight epithelioid-type MM cases (62.5%), while also observing loss in both sarcomatoid and epithelioid components in five of 13 biphasic-type MM cases (38.5%)."
33153245
reach
"Our results suggested that, whereas WT BAP1 suppresses MM cell proliferation and restores cell survival after IR damage, some mutant BAP1 may also moderately retain these functions."
26011428
reach
"Loss of BAP1 is frequently observed in MM and has been proven to increase the risk of MM [XREF_BIBR - XREF_BIBR]."
28978163
reach
"Transduction of the WT BAP1 vector inhibited cell proliferation of the Y-MESO-25 MM cell line with BAP1 deletion by approximately 50% compared to the cells with control vector (GFP)."
26011428
reach
"With the colony formation assay, we also found that WT BAP1 suppressed the anchorage independent cell growth of the MM cells with BAP1 deletion, whereas mutant BAP1 showed little or no reduced effect."
26011428