IndraLab

Statements

Progesterone inhibits NLRP3. 8 / 8
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"Progesterone decreased NLRP3 inflammasome activity with an increase in autophagy induction in estrogen-treated NESCs."
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"It’s noteworthy to mention that previous research has indicated that progesterone can inhibit the NLRP3 inflammasome in N. gonorrhoeae-infected macrophages and mice."
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"In a report by Aryanpour et al., progesterone gave rise to a switch from pro-inflammatory to anti-inflammatory microglia phenotype and inhibited the functions of NLRP3 inflammasome in a cuprizone-indu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Progesterone was reported to significantly inhibit the Aβ-induced activation of the NLRP3 inflammasome in astrocytes by mitigating endoplasmic reticulum stress (Yang et al., 2020)."
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"These results are in agreement with another report which indicates that progesterone therapy induces a switch in microglia phenotype from pro inflammatory to anti-inflammatory and suppresses NLRP3 inflammasome in cuprizone induced demyelination mice (Aryanpour et al., 2017)."
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"52 Female reproductive hormones, estrogen and progesterone, suppress inflammatory immune responses and NLRP3 inflammasome function."
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"In monocytes from preeclampsia-affected pregnant women, progesterone and vitamin D inhibited the activation of the TLR4-MyD88-NF-κB pathway and the NLRP1/NLRP3 inflammasomes (165)."
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"However, the functional pathway through which progesterone inhibits NLRP3 in endometrial cells remains unknown."
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