IndraLab

Statements

Progesterone inhibits NLRP3. 4 / 4
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"52 Female reproductive hormones, estrogen and progesterone, suppress inflammatory immune responses and NLRP3 inflammasome function."
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"Progesterone and vitamin D downregulate the activation of the NLRP1 and NLRP3 inflammasomes and TLR4-MyD88-NF-kappaB pathway in monocytes from pregnant women with preeclampsia."
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"Progesterone decreased NLRP3 inflammasome activity with an increase in autophagy induction in estrogen-treated NESCs."
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"These results are in agreement with another report which indicates that progesterone therapy induces a switch in microglia phenotype from pro inflammatory to anti-inflammatory and suppresses NLRP3 inflammasome in cuprizone induced demyelination mice (Aryanpour et al., 2017)."
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