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USP4 inhibits Neoplasm Invasiveness. 4 / 4
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"Interestingly, we were also able to observe that USP4 knockdown in SW480 cells increased invasion activity under the same experimental conditions as used in HCT116 cells, suggesting that the role of U[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP4 can inhibit NF-κB activation through deubiquitination of TRAF2 and TRAF6, thereby promoting cell migration and invasion in lung cancer (46)."
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"Results Showed that MMP2, VEGF after silencing USP4 expression The expression of e-cadherin was decreased, while the expression of N-cadherin was increased, indicating that downregulation of USP4 expression inhibited the invasion ability of cells (Fig. 4D)."
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"Then we confirmed that USP4 downregulation inhibited malignant biological behaviors, such as cell proliferation, migration and invasion in PC."
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