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OTUD3 inhibits HSPA5. 4 / 4
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"Western blotting analysis showed that OTUDin3 downregulated GRP78 in a time-dependent manner, and the downregulation effect was significant after 24 h (Fig. 4A)."
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"Then, H1299 cells were treated with increasing concentrations of OTUDin3 for 24 h. Western blotting analysis showed that OTUDin3 downregulated GRP78 in a concentration-dependent manner without affecting the stability of OTUD3 (Fig. 4B)."
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"OTUDin3 enhanced degradation of the substrate GRP78 by inhibiting the deubiquitinating activity of OTUD3."
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"OTUDin3 downregulates GRP78 by inhibiting the deubiquitinating activity of OTUD3."
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