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USP2 deubiquitinates CEBPA. 3 / 3
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"Importantly, by deubiquitinating CCAAT/enhancer binding protein alpha (C/EBPα), USP2 also regulates 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1), thereby playing a vital role in the homeostasis of glucocorticoids within liver cells16.In this study, we found that high dietary fructose consumption promotes MASLD development and progression in C57BL/6J mice, identified Usp2 as a specific fructose-responsive gene, and revealed that the USP2-mediated C/EBPα/11β-HSD1 signaling is involved in disrupting cortisol homeostasis."
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"Lin’s team reported that USP2 mediates the deubiquitylation of Cebpa and induces the expression of the 11β-hydroxysteroid dehydrogenase 1 (Hsd1) gene, thereby enhancing glucocorticoid signaling and stimulating hepatic gluconeogenesis [44]."
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"Importantly, by deubiquitinating CCAAT/enhancer binding protein alpha (C/EBPα), USP2 also regulates 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1), thereby playing a vital role in the homeostasis of glucocorticoids within liver cells16.In this study, we found that high dietary fructose consumption promotes MASLD development and progression in C57BL/6J mice, identified Usp2 as a specific fructose-responsive gene, and revealed that the USP2-mediated C/EBPα/11β-HSD1 signaling is involved in disrupting cortisol homeostasis."
38993560