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BAP1 deubiquitinates PRKDC. 2 / 2

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"Our results suggest reciprocal positive interactions between BAP1 and DNA-PKcs, based on phosphorylation of BAP1 by the latter and deubiquitination of DNA-PKcs by BAP1."

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"Activated DNA-PK phosphorylates BRCA1-associated protein 1 (BAP1) at S395, and BAP1, in turn, deubiquitinates DNA-PKcs, establishing a positive feedback loop between the two (Sato et al., 2024)."

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BAP1 deubiquitinates PRKDC. 2 / 2

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