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USP22 deubiquitinates STING1. 5 / 6
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"We furthermore demonstrate for the first time that in the absence of viral 421 infections or exogenous IFN, loss of USP22 expression resulted in basal and 2'3'-422 cGAMP-induced STING ubiquitination in hIECs."
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"USP22 negatively regulates STING activation and ubiquitination."
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"USP22 negatively regulates STING activation and ubiquitination."
35933402
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"288 289 USP22 negatively regulates STING activation and ubiquitination 290 The differential response to ISD, but not poly(I:C), and the reversal of the IFN signature 291 in USP22-STING dKO hIECs suggests an important role of USP22 in the control of 292 STING-induced type III IFN signaling."
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"However, USP22 does not seem to have a clear specificity in terms of its selectivity for PPARγ deubiquitination, and studies have reported that USP22 can deubiquitinate ATG5 and STING ."
40301680