IndraLab

Statements

USP22 leads to the deubiquitination of STING1. 4 / 4
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"USP22 negatively regulates STING activation and ubiquitination."
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"We furthermore demonstrate for the first time that in the absence of viral 421 infections or exogenous IFN, loss of USP22 expression resulted in basal and 2'3'-422 cGAMP-induced STING ubiquitination in hIECs."
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ubibrowser
"USP22 removes K27-linked ubiquitination on STING through cooperation with USP13"
29732405
reach
"288 289 USP22 negatively regulates STING activation and ubiquitination 290 The differential response to ISD, but not poly(I:C), and the reversal of the IFN signature 291 in USP22-STING dKO hIECs suggests an important role of USP22 in the control of 292 STING-induced type III IFN signaling."
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