IndraLab

Statements

CD274 increases the amount of CD44. 6 / 6
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"Here, we have also pointed out that PD-L1 suppression reduces surface CD44 expression and may be through an autocrine regulation.ALDH1 is associated with poor prognosis in different human malignancies[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, low IFN-gamma doses and PD-L1 modulation both promoted plastic changes in NSCLC-B, increasing CD44 expression and its ability to produce spheres."
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"Mechanistically, CD44 activated PD-L1 transcription in part through its cleaved intracytoplasmic domain (ICD), which bound to a regulatory region of the PD-L1 locus containing a consensus CD44-ICD binding site."
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"Further, PD-L1 knockdown in breast cancer cells downregulated the expression of CD44 and upregulated the expression of CD24 [63], suggesting that PD-L1 expression positively regulates stem-like cells activity in the cancer tissues [56]."
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"Together, these data suggested that PD-L1 on NSCLC-B cells directly regulates CD44 expression and that its inhibition leads to increased tumor cell growth, both in 3D anchorage-independent and 2D cell culture assays, suggesting a relevant role of PD-L1 in both cancer cell stemness modulation and tumor growth."
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"Recently, Lotfinejad et al. have shown that inhibiting tumoral PD-L1 can substantially decrease CD44 expression in TNBC cells (37)."
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