IndraLab

Statements

Amodiaquine activates NR4A2. 10 / 10
| 2 7 1
reach
"Interestingly, amodiaquine stimulate the transcriptional function of Nurr1 by physical interaction with its ligand binding domain (LBD)."
33507465
reach
"We previously demonstrated that the pharmacological stimulation of Nurr1 by amodiaquine (AQ) promotes spatial memory by enhancing adult hippocampal neurogenesis."
31861329
reach
"Two antimalarial drugs, amodiaquine (AQ) and chloroquine stimulated the transcriptional function of Nurr1 and enhanced the Nurr1 dependent transcriptional activation of DA specific genes."
| PMC
reach
"We have systematically studied the structure activity relationship of the 4-amino-7-chloroquinoline scaffold contained in Nurr1 activators amodiaquine and chloroquine and discovered fragment like analogues that activated Nurr1 in several cellular settings."
33629841
reach
"In particular, we found that two antimalarial drugs, amodiaquine and chloroquine stimulate the transcriptional function of Nurr1 through physical interaction with its ligand binding domain (LBD)."
26124091
reach
"However, the signaling route by which Nurr1 is activated by amodiaquine to cause the protective effect remains to be elucidated."
33507465
reach
"To identify novel Nurr1 agonist chemotypes, we have employed the Nurr1 activator amodiaquine as template for microscale analogue library synthesis."
35132775
eidos
"However , the signaling route by which Nurr1 is activated by amodiaquine to cause the protective effect remains to be elucidated ."
33507465
eidos
"We previously demonstrated that the pharmacological stimulation of Nurr1 by amodiaquine ( AQ ) promotes spatial memory by enhancing adult hippocampal neurogenesis ."
31861329
sparser
"However, the signaling route by which Nurr1 is activated by amodiaquine to cause the protective effect remains to be elucidated."
33507465