IndraLab

Statements

Amodiaquine activates NR4A2. 14 / 15
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"Subsequent in vitro studies in 293T cells report that amodiaquine activated NR4A1- NR4A2- and NR4A3-dependent transactivation suggesting that this compound may be a unique pan-NR4A ligand."
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"To identify novel Nurr1 agonist chemotypes, we have employed the Nurr1 activator amodiaquine as template for microscale analogue library synthesis."
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"We previously demonstrated that the pharmacological stimulation of Nurr1 by amodiaquine (AQ) promotes spatial memory by enhancing adult hippocampal neurogenesis."
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"However, the signaling route by which Nurr1 is activated by amodiaquine to cause the protective effect remains to be elucidated."
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"Two antimalarial drugs, amodiaquine (AQ) and chloroquine stimulated the transcriptional function of Nurr1 and enhanced the Nurr1 dependent transcriptional activation of DA specific genes."
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"In particular, we found that two antimalarial drugs, amodiaquine and chloroquine stimulate the transcriptional function of Nurr1 through physical interaction with its ligand binding domain (LBD)."
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"However , the signaling route by which Nurr1 is activated by amodiaquine to cause the protective effect remains to be elucidated ."
33507465
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"We previously demonstrated that the pharmacological stimulation of Nurr1 by amodiaquine ( AQ ) promotes spatial memory by enhancing adult hippocampal neurogenesis ."
31861329
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"We have employed the weak Nurr1 modulator amodiaquine (AQ) and AQ-derived fragments as templates to design a new Nurr1 agonist chemotype by scaffold hopping and fragment growing strategies."
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"We have systematically studied the structure activity relationship of the 4-amino-7-chloroquinoline scaffold contained in Nurr1 activators amodiaquine and chloroquine and discovered fragment like analogues that activated Nurr1 in several cellular settings."
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"Interestingly, amodiaquine stimulate the transcriptional function of Nurr1 by physical interaction with its ligand binding domain (LBD)."
33507465
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"However, the signaling route by which Nurr1 is activated by amodiaquine to cause the protective effect remains to be elucidated."
33507465
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"We identified three drugs, i.e., amodiaquine (AQ), chloroquine (CQ), and glafenine, which significantly enhance the transcriptional activity of Nurr1 through direct binding to its ligand binding domain (LBD) ."
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"NSAIDs and amodiaquine simultaneously modulate Nurr1."
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