IndraLab

Statements

MIR21 inhibits CYLD. 4 / 5
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"Another finding indicated that miR-21 and miR-181b-1 both repressed PTEN as well as CYLD, which were subsequently turned on by STAT3 in the signaling [71]."
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"IL-6 also activates STAT3 causing direct activation of miR-21 and miR-18b-1, which respectively inhibit PTEN and CYLD (tumor suppressor genes)."
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"has shown that miR-21, together with miR-181b-1, inhibit PTEN and cylindromatosis (CYLD) tumor suppressor functions, respectively, leading to increased NF-kB activity thus underlying the epigenetic switch that links inflammation to cancer."
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"This suggests that these miRNAs are part of the regulatory circuit, and indeed they found that their expression is regulated by IL-6 and that both miR-21 and miR-181b-1 can activate NF-kappaB by targeting and inhibiting the tumour suppressors PTEN and CYLD [XREF_BIBR]."
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