IndraLab

Statements

TWIST1 binds USP4. 6 / 6
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"Co-Immunoprecipitation assay showed that USP4 interacted with Twist1 ( xref D)."
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"Thus, targeting the USP4–Twist1 axis may represent a novel therapeutic approach for lung cancer treatment."
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"Our data indicate that USP4 stabilizes Twist1 to promote lung cancer cell stemness, which prompted us to verify the clinical relevance of USP4–Twist1 in human lung cancer."
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"In this study, we uncover that USP4 is a novel deubquitinase of Twist1 and that silencing of Twist dramatically inhibits USP4-induced stemness of lung cancer cells, suggesting that the USP4–Twist1 axis plays a critical role in lung cancer stemness."
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"Together, these results indicate that the USP4–Twist1 axis plays a critical role in lung cancer stemness and clinical prognoses ( xref E)."
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sparser
"To this end, we first asked whether USP4 can form a stable protein complex with Twist1."
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