IndraLab

Statements

Silibinin inhibits CHUK. 3 / 3
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"Using multiple inhibitors of TNF-alpha and LPS signaling, we found that two inhibitors, silibinin (an inhibitor of IKKalpha) and NSC33994 (a Jak2 inhibitor) possess the ability to inhibit TNF-alpha and LPS induced USP18 expression and proinflammatory effects."
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"Silibinin inhibited the constitutive activation of NF-kappaB and IKKalpha in PC-3 and DU-145 cells, and blocked stimulated activation of NF-kappaB in LNCaP cells."
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"Meanwhile, only two inhibitors potently (> 80%) inhibited USP18 expression as well as IL-1beta mRNA expression in response to LPS stimulation; NSC33994 (an inhibitor of Jak2) and silibinin (an inhibitor of IKKalpha) (XREF_FIG and XREF_FIG and XREF_TABLE)."
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