IndraLab

Statements

KCNH2 activates cell migration. 4 / 5
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reach
"These interactions collectively facilitate the anchoring of ESEE to the binding site of hERG.Conformational changes in the voltage-gated structural domains of hERG channels can directly interact with integrin β1 and FAK in lipid rafts to promote cell migration, which is a key factor in cancer metastasis."
39307030
reach
"For instance, in human acute myeloid leukemia cells, hERG1 channels appear to mediate the vascular endothelial growth factor receptor-1-dependent cell migration and invasion, both in vitro and in vivo."
18663136
reach
"By combining experimental data and quantitative modeling, we defined a novel signaling pathway by which β1 integrins and hERG1 interact to regulate f-actin organization and promote cell migration."
37923359
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"We conclude that in AML, hERG1 channels mediate the FLT-1-dependent cell migration and invasion, and hence confer a greater malignancy."
17420287