IndraLab

Statements

KCNH2 activates cell migration. 3 / 4
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"Activation of HERG with PD118057 stimulated cell migration."
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"For instance, in human acute myeloid leukemia cells, hERG1 channels appear to mediate the vascular endothelial growth factor receptor-1-dependent cell migration and invasion, both in vitro and in vivo."
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"We conclude that in AML, hERG1 channels mediate the FLT-1-dependent cell migration and invasion, and hence confer a greater malignancy."
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