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Angiotensin-2 activates COPS6. 3 / 3
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"However, the specific DUB and the molecular mechanism that play roles in Ang-II induced pathological myocardial hypertrophy is still unclear.Deubiquitinase CSN6 belongs to JAMM/MPN domain-associated m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the current study, we reported that Ang II induced the upregulation of CSN6, a deubiquitinase belongs to JAMMs class, in cardiomyocytes both in vivo and in vitro ."
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"Overall, our results indicated that CSN6 promoted Ang II-induced cardiac hypertrophy.Next, to determine molecular event of CSN6 regulating Ang II-induced myocardial hypertrophy, we applied high-throug[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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