IndraLab

Statements

USP13 inhibits cell population proliferation. 12 / 12
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"USP13 knockdown in BC cells promoted their proliferation, invasion and migration."
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"Treatment with afatinib alone diminished the number of proliferating cells to approximately 36%, while USP13 shRNA only slightly decreased cell proliferation."
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"By contrast, KD of USP13 only modestly reduced proliferation of cell lines with low USP13 expression (SKOV3 and IGROV1) (XREF_FIG; XREF_SUPPLEMENTARY)."
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"Next, we treated infected THP-1 cells with a cell-permeable potent autophagy inhibitor, spautin-1.58 Spautin-1 promotes the degradation of BECN1 by inhibiting 2 USPs (ubiquitin-specific peptidases), USP10 and USP13, which target BECN1.58 Spautin-1 treatment of infected cells significantly decreased E. chaffeensis proliferation (Fig. 3B)."
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"As a results, downregulation of USP13 dramatically inhibited A549 and H226 cell proliferation by AKT and MAPK signaling and suppressed tumor growth in nude mice."
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"Overexpression of miR-130b/301b or USP13 knockdown by shRNA delivery decreases USP13 expression, and further reduces PTEN protein expression and leads to enhancement of cell proliferation, invasion and migration."
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"Moreover, knockdown of USP13 promoted the proliferation of HCT116 colon cancer cells but not the isogenic PTEN-null HCT116 cells (XREF_FIG)."
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"Functional studies demonstrated that overexpression of USP13 suppressed OSCC cell proliferation, glucose uptake and lactate production in vitro and inhibited tumor growth in vivo."
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"Meanwhile, silencing of USP13 greatly enhanced proliferation, invasion and migration of the tested cells."
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"Depletion of USP13 inhibited cervical cancer cell proliferation."
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"In two other USP13 high HGSC cell lines (OAW28 and OVCAR3) XREF_BIBR, silencing USP13 also profoundly inhibited cell proliferation (XREF_SUPPLEMENTARY)."
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"miR-135b promoted cell proliferation and glycolysis that could be reversed by the overexpression of USP13 or PTEN."
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