IndraLab

Statements

USP13 inhibits cell population proliferation. 22 / 22
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"USP13 knockdown in BC cells promoted their proliferation, invasion and migration."
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"By contrast, KD of USP13 only modestly reduced proliferation of cell lines with low USP13 expression (SKOV3 and IGROV1) (XREF_FIG; XREF_SUPPLEMENTARY)."
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"Treatment with afatinib alone diminished the number of proliferating cells to approximately 36%, while USP13 shRNA only slightly decreased cell proliferation."
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"In two other USP13 high HGSC cell lines (OAW28 and OVCAR3) XREF_BIBR, silencing USP13 also profoundly inhibited cell proliferation (XREF_SUPPLEMENTARY)."
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"Overexpression of miR-130b/301b or USP13 knockdown by shRNA delivery decreases USP13 expression, and further reduces PTEN protein expression and leads to enhancement of cell proliferation, invasion and migration."
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"Functional studies demonstrated that overexpression of USP13 suppressed OSCC cell proliferation, glucose uptake and lactate production in vitro and inhibited tumor growth in vivo."
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"For example, overexpression of USP13 blocks the AKT signaling pathway and suppresses tumor cell proliferation, invasion, and glycolysis by upregulating PTEN, while USP13 levels are downregulated in breast, bladder, and oral squamous tumors, in correlation with PTEN levels (Fig. 3)."
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"USP13 overexpression inhibited the proliferation of and glycolysis in OSCC cells in vitro and suppressed tumorigenesis in nude mice."
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"USP13 overexpression repressed cell proliferation and the Warburg effect in OSCC cells."
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"USP13 loss leads to decreased ccRCC cell proliferation in vitro and tumor growth in vivo."
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"Our 2D colony growth assays or soft agar growth assays showed that USP13 short hairpin RNA led to decreased cell proliferation, the phenotype ameliorated at least partially by ZHX2 overexpression in these cells (SI Appendix, Fig. S4 D–I and Fig. 3 H–J)."
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"As a results, downregulation of USP13 dramatically inhibited A549 and H226 cell proliferation by AKT and MAPK signaling and suppressed tumor growth in nude mice."
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"Ectopic expression of USP13 suppressed cell proliferation, glycolysis, and tumorigenicity."
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"Accordingly, we propose that USP13 inhibits the proliferation and glycolysis of OSCC cells via the upregulation of PTEN and the downregulation of AKT activity."
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"Moreover, knockdown of USP13 promoted the proliferation of HCT116 colon cancer cells but not the isogenic PTEN-null HCT116 cells (XREF_FIG)."
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"Depletion of USP13 inhibited cervical cancer cell proliferation."
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"miR-135b promoted cell proliferation and glycolysis that could be reversed by the overexpression of USP13 or PTEN."
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"Moreover, our results demonstrated that downregulation of USP13 inhibited HCC cell proliferation, while its overexpression promoted cellular proliferation."
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"These findings confirm that the USP13/PARP1 axis positively regulates the DDR of MM cells, promoting MM cell proliferation.3.6 BA Inhibits MM Cell Proliferation in Vitro by Targeting the USP13/PARP1 Axis."
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"In vitro, USP13 over-expression in BMDMs inhibits the proliferation of fibroblast-like synoviocytes (FLS) and osteoclastogenesis."
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"Also, EdU as well as colony-formation assays further confirmed downregulating USP13 suppressed cell proliferation whereas upregulation of USP13 significantly promoted cell proliferation in OS cells (Fig. 1c, d and S2c, d)."
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"Meanwhile, silencing of USP13 greatly enhanced proliferation, invasion and migration of the tested cells."
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