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ADAM17 activates NOTCH1. 26 / 31
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"GRWD1 over-expression increased ADAM metallopeptidase domain 17 (ADAM17) expression and promoted Notch1 intracellular domain (NICD) release to promote GC cell proliferation, migration, and invasion in vitro."
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"In this study, we discovered that iRhom2 regulate murine hair follicle differentiation by specifically modulating Notch1 and Wnt signaling pathway which maybe mediated by TACE."
25546423
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"TACE/ADAM17 is activated to regulate the Notch1 signaling."
35800881
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"Intriguingly, A reverse signaling mechanism of anti-TNF-a agents could modulate TACE which in turn modulates Notch-1 cleavage and its subsequent activation (9, 10) ."
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"This study identifies that iRhom2 regulates hair shaft and IRS differentiation by specifically modulating Notch1 and Wnt signaling pathway which maybe mediated by TACE."
25546423
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"Moreover, in vitro and in vivo data have shown that NOTCH1 activation by ADAM17 results in the tumorigenicity of NSCLC cells [XREF_BIBR]."
| PMC
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"Furthermore, we found that TACE dependent activation of Notch1 in basal kerantinocytes was modulated by uPAR."
26527290
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"Based on publications showing increased ADAM activity upon Ca 2+ flux and PI3K and MAPK dependent phosphorylation changes, we hypothesized that anti-CD20 monoclonal antibodies could enhance ADAM10 and ADAM17 mediated NOTCH1 cleavage."
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"After activation, Notch can be cleaved to its intracellular domain (NICD) by ADAM10, TACE and gamma-secretase, allowing the NICD to become capable of target gene activation [XREF_BIBR]."
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"Initially, two independent groups concluded that ADAM17 (TNF-alpha converting enzyme, TACE) initiates signaling by performing S2 cleavage of the Notch1 receptor."
21236490
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"Endothelial specific knockdown of Adam17 reduced collateral formation, consistent with its roles in endothelial cell migration and embryonic vascular stabilization, but not in activation of ligand bound Notch1."
22965144
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"Furthermore, we found that TACE-dependent activation of Notch1 in basal kerantinocytes was modulated by uPAR."
26527290
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"The precise steps responsible for activating Notch1 in the venous beds of mutant mice require further study, but we note that Dll4 itself can exert long-distant effects following its release into exosomes and that ADAM 17 (up-regulated more than 2-fold in Snail1 KO ECs) can activate Notch1 signaling in a ligand independent fashion XREF_BIBR, XREF_BIBR."
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"Moreover, in vitro and in vivo data have shown that NOTCH1 activation by ADAM17 results in the tumorigenicity of NSCLC cells [ xref ]."
| PMC
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"Notch signaling is activated by binding of DSL ligands to the Notch receptor, which induces proteolytic cleavage of Notch by ADAM and TACE metalloproteases and subsequent cleavage by gamma-secretase to generate the Notch intracellular signaling fragment NICD XREF_BIBR, XREF_BIBR."
24244188
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"Keratinocyte-specific loss of the metalloproteinase ADAM17 leads to reduced ligand-independent Notch-1 and -2 signaling, known to suppress production of TSLP, and these mice develop a severe form of a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26200011
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"The absence of ADAM17-mediated Delta-like cleavage fits our model that ADAM17 activates Notch1, possibly by releasing Jagged-1 and -2, and promotes the CSC phenotype in CRC cells."
26744411
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"Initially, two independent groups using in vitro models concluded that ADAM17 (TNF converting enzyme) initiates Notch1 signaling by cleaving Notch1 in monocytic precursors and MEFs."
20156974
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"This study suggests that iRhom2 regulates hair shaft and IRS differentiation by specifically modulating Notch1 and Wnt signaling pathway which maybe mediated by TACE."
25546423
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"Further studies determined that ADAM10 is indispensable for ligand induced NOTCH1 signaling and ADAM17 mediates ligand independent NOTCH1 cleavage [XREF_BIBR, XREF_BIBR]."
27224017
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"Similarly, expression of exogenous Adam10 or Adam17 in mouse embryonic fibroblasts (MEFs) derived from Adam10 and Adam17 knockout animals, effectively increased activation of NOTCH1 signaling upon expression of activated forms of NOTCH1 in these cells (XREF_FIG)."
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"The activation of Notch1 by ADAM17 and the subsequent regulation of the EGFR expression are required for the tumorigenicity of NSCLC cells [ xref ]."
27378579
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"iNOS and nitric oxide promote ADAM17-mediated Notch1 activation in liver cancer stem cells, leading to a more aggressive cancer phenotype [37]."
36572816
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"DeltaE TM is very analogous to the natural TACE processing product of Notch1 that is generated after ligand binding."
15240571
eidos
"Moreover , in vitro and in vivo data have shown that NOTCH1 activation by ADAM17 results in the tumorigenicity of NSCLC cells [ 46 ] ."
| PMC
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"The absence of ADAM17 mediated Delta like cleavage fits our model that ADAM17 activates Notch1, possibly by releasing Jagged-1 and -2, and promotes the CSC phenotype in CRC cells."
26744411