IndraLab

Statements

Salicylate inhibits NLRP3. 9 / 9
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"Moreover, inhibition of NLRP3 by SAL is dependent on autophagy activation, as this change can be reversed by an autophagy inhibitor 3-MA in HUVECs with LPS exposure."
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"In mice with acute liver injury induced by carbon tetrachloride, treatment with SAL effectively inhibited the activation of the NLRP3 inflammasome and alleviated liver damage [39]."
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"Moreover, SAL inhibited the activation of the TXNIP/NLRP3 inflammasome axis and mitigated the neuronal loss of spinal dorsal horn induced by nerve injury."
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"Furthermore, Sal B reduced the expression levels of IL-1beta and NLRP3 inflammasome in a dose dependent manner."
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"SAL Restores the LPS-Induced Decrease in AMPK Activity and Prevents Activation of the NLRP3 Inflammasome in A549 Cells."
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"Our study shows that SAL inhibited NLRP3 inflammasome pathway in LPS induced HUVECs, with reduced expression of NLRP3, ASC and caspase-1."
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"Our data indicate that SAL inhibit NLRP3 related pyroptosis, which might be the underlying mechanism of SAL anti-inflammatory in atherosclerosis."
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"The protective effects of SAL were mainly associated with enhanced autophagy and suppressed NLRP3 signaling pathway."
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"SAL Decreases ROS Production and Suppresses the NLRP3 Inflammasome in an AMPK-Dependent Manner."
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