IndraLab

Statements

Salicylate inhibits NLRP3. 20 / 20
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"Furthermore, Sal B reduced the expression levels of IL-1beta and NLRP3 inflammasome in a dose dependent manner."
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"In addition, SAL activated the Nrf2 antioxidant pathway through SIRT1, induced autophagy, and attenuated NLRP3 inflammasome development."
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"Moreover, SAL inhibited the activation of the TXNIP/NLRP3 inflammasome axis and mitigated the neuronal loss of spinal dorsal horn induced by nerve injury."
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"Sal inhibited brain injury induced by MCAO/R in rats and inhibited the NLRP3 inflammasomes activation in microglia."
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"Altogether, we confirmed the mechanisms of Sal B reduce glycolysis, NLRP3, and M1 polarization are partly associated with the inhibitory effect on LDHA."
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"Our data indicate that SAL inhibit NLRP3 related pyroptosis, which might be the underlying mechanism of SAL anti-inflammatory in atherosclerosis."
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"This showed that Sal can reduce the activation of NLRP3 inflammasomes in microglia induced by MCAO/R."
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"Sal B reduced MI injury by inhibiting the SIRT1-AMPK-PGC-1 signaling pathway’s activation of the NLRP3 inflammasome [15]."
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"SAL suppressed LPS-promoted NLRP3 inflammasome To determine the NLRP3 protein levels and associated proteins, we employed western blotting (Figure 6a)."
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"In an in vitro model of PC12 cell injury induced by D-gal and nigericin, Sal reversed TLR4, MyD88, NF-κB, P-NF-κB, NLRP3, and ASC and cleaved Caspase-1 and increased the protein expression of cleaved GSDMD, IL-1β and IL-18."
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"The protective effects of SAL were mainly associated with enhanced autophagy and suppressed NLRP3 signaling pathway."
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"SAL Restores the LPS-Induced Decrease in AMPK Activity and Prevents Activation of the NLRP3 Inflammasome in A549 Cells."
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"Our results demonstrated that SAL could attenuate oxidative stress and the development and activation of the NLRP3 inflammasome induced by LPS, which is consistent with the previous study."
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"Our study shows that SAL inhibited NLRP3 inflammasome pathway in LPS induced HUVECs, with reduced expression of NLRP3, ASC and caspase-1."
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"SAL Decreases ROS Production and Suppresses the NLRP3 Inflammasome in an AMPK-Dependent Manner."
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"However, it has remained unclear whether Sal can inhibit the inflammatory response to cerebral ischemia by inhibiting activation of the NLRP3 inflammasome in microglia."
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"SAL reduced obesity, abnormal blood glucose and liver lipid deposition in NAFLD mouse model by regulating ROS and AMPK-dependent TXNIP/NLRP3 pathways (201)."
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"Wang et al. (100) showed that SAL inhibited TXNIP/NLRP3 signaling pathway in rat glomerular mesangial cells.Notoginsenoside Fc (Fc) is a novel saponin extracted from Panax notoginseng with excellent anti-platelet aggregation ability (178)."
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"Moreover, inhibition of NLRP3 by SAL is dependent on autophagy activation, as this change can be reversed by an autophagy inhibitor 3-MA in HUVECs with LPS exposure."
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"In mice with acute liver injury induced by carbon tetrachloride, treatment with SAL effectively inhibited the activation of the NLRP3 inflammasome and alleviated liver damage [39]."
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