IndraLab

Statements

Mutated KCNH2 inhibits potassium(1+). 3 / 3
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"KvLQT1 and HERG mutations (one each) reduced K+ currents in vitro, consistent with the idea that they augment risk for aLQTS."
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"Furthermore, hERG mutation also impairs the potassium ion channels and induces cell apoptosis as well as endoplasmic reticulum (ER) stress that impacts many cardiac functions [7]."
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"HERG mutations reduce the outward flow of potassium during repolarization and elongate the QT interval leading to polymorphic ventricular tachycardia, cardiac syncope, and sudden death."
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