IndraLab

Statements

Paclitaxel inhibits NFKBIA. 4 / 4
| 4
reach
"TNF-alpha and taxol induce degradation of IkappaBalpha."
19732770
reach
"Consistent with endogenous activation of NF-kappaB signaling by taxol we showed that, similar to TNF-alpha, taxol treatment in the presence of cycloheximide significantly reduced IkappaBalpha suggesting that both molecules induce proteasomal degradation of IkappaBalpha."
19732770
reach
"When compared to the background loss of IkappaBalpha in a 4-h period, TNF-alpha or taxol caused the degradation of IkappaBalpha by ~ 40% (XREF_FIG)."
19732770
reach
"Both TNF-alpha and taxol induce the degradation of endogenous IkappaBalpha and either taxol or TNF-alpha induction of NF-kappaB activity was blocked by inhibitors of NF-kappaB acting at different sites in the signaling pathway."
19732770