IndraLab

Statements

UCHL1 inhibits TP53. 5 / 5
| 5
reach
"When the expression level of UCH-L1 increases, UCH-L1 further activates and stabilizes p53 signaling by inhibiting the degradation of p53, leading to cell cycle arrest at G0/G1 and apoptosis (Fig. 4) (26)."
36844618
reach
"Moreover, Li et al. showed that UCHL1 promotes tumor suppressor p53 signaling and is silenced due to its promotion of methylation in nasopharyngeal carcinoma [64]."
31240215
reach
"On the other hand, UCH-L1 decreases degradation of p53 by interfering with ubiquitination of p53 and further stabilizes p53 expression, and ultimately inhibits proliferation of cancer cells (Fig. 4) (25)."
36844618
reach
"Interestingly, UCHL1 promotes p53 signaling in nasopharyngeal carcinoma 40 and PADI2 facilitates p53 degradation in breast cancer cells."
32248654
reach
"It is also possible that UCH-L1 indirectly elicits control over p53 by modulating negative regulators of p53, such as mdm2, as suggested by Li et al. [XREF_BIBR]."
22811913