IndraLab

Statements

COPS5 inhibits PPP1R9B. 2 / 2
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"Consistently, JAB1 overexpression in APP/PS1 transgenic mice significantly increased amyloidogenic processing of APP, and reduced spinophilin (the marker of dendritic spines) in both the cortex and the hippocampus, leading to significant defects in learning and memory skills (Wang et al. 2015)."
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"Furthermore, COPS5 overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills."
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