IndraLab

Statements

USP25 increases the amount of IFNB1. 2 / 2
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"Usp21 ablation also drastically enhanced the expression of Ifnb, Ifna4, or TNF mRNA in primary PEMs (peritoneal macrophages; XREF_FIG) or BMDMs (BM derived macrophages; XREF_FIG)."
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"USP25 's DUB activity was also found to be necessary for virus induced signaling, as USP25 knockdown MEFs with WT USP25 reconstitution allowed expression of Ifnb, Ifna4 and IL-6 upon SeV or HSV-1 induction, while those with DUB activity mutant USP25 did not [XREF_BIBR]."
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