IndraLab

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SART3 inhibits USP15. 2 / 2
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"The complex structure of the NLS on Tip110 and importin 2α is involved a bipartite binding, and removal of Tip110 NLS prevents the entry of USP4 or USP15 in the nucleus and abrogates their subsequent deubiquitinase activity (12, 55), which may explain the detection of a higher ubiquitinated form of cytoplasmic expressed Tip110ΔNLS mutant ( Figures 2D , 4C, E )."
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"We showed that USP15 expression obliterated Tip110-induced NF-κB activation ( Figures 5B, C ) and overexpression of Tip110 enhanced USP15-inhibited NF-κB activity ( Figures 5D, E )."
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