IndraLab

Statements

USP12 activates IFNB1. 6 / 6
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"Furthermore, USP12 significantly enhanced the IFN-β promoter activity mediated by IFI16/STING but not by TLR9/MYD88 and DDX41/STING (Fig 4A)."
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"By contrast, USP12 enhanced IFN-β, NF-κB, and ISRE promoter activities in a dose-dependent manner after cotransfection with IFI16 (Fig 4B)."
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"Results show that USP12 deficiency significantly inhibited IFN-β, CXCL5, and IL-6 production in BMDMs and MEFs infected with a DNA virus, although not in BMDMs infected with an RNA virus (Figs 1A and S2A)."
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"The exogenous overexpression of USP12 in HEK293T cells promoted DNA-virus induced luciferase activities of IFN-β, ISRE, and NF-κB promoters (Fig 1C)."
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"Similarly, the knockdown of USP12 decreased IFN-β, CCL5, and IL-6 production in the DNA virus infected-groups but not in the RNA virus infected-group (Fig 2A)."
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"The overexpression of human USP12 promoted DNA virus-induced luciferase activities of IFN-β, ISRE, and NF-κB promoters."
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