IndraLab

Statements

TNFAIP3 activates TLR. 4 / 4
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"Indeed, these 3 genes encodes for negative regulators of NF-κB signaling pathway: IL-1 receptor-associated kinase 3 (IRAK3) inhibits IRAK1/4 at the MyD88 complex; Tnfaip3 codes for the deubiquitinase A20, which removes poly-ubiquitin chains from TNF receptor-associated factor 6 (TRAF6); TRAF1 interferes with the linear ubiquitination of NEMO by the LUBAC complex.Several signaling molecules downstream of BCR synergize with TLR pathways to modulate the TLR response."
34434197
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"However, polymorphisms genes encoding proteins and transcription factors downstream of TLR activation, including TNFAIP3, TNIP1 and IRF5, correlate with lupus risk [XREF_BIBR, XREF_BIBR]."
25679954
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"Mice adoptively transferred with TNFAIP3 -/- x Myd88 -/- hematopoietic stem cells display decreased inflammatory activation in the intestine demonstrating that the control of immune cell TLR signaling by TNFAIP3 is also required for intestinal homeostasis XREF_BIBR."
22031828
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"83 In ABC DLBCL, biallelic inactivation of TNFAIP3 (by mutations, deletions or both) occurs in 30% of cases and can coexist with mutations in both MYD88 and CD79B, suggesting that inactivation of TNFAIP3 can enhance both BCR and TLR signalling pathways."
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