IndraLab

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USP28 inhibits cell cycle. 3 / 3
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"As expected, USP28 overexpression further decreased the relative expression of cell cycle related genes (CDK4, CDK6, Cyclin D1, pRB, and E2F1) induced by 5 '-AZA, whereas p15 and p27 expression was significantly enhanced."
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"These extended mitosis trigger the activation of 53BP1 and USP28 which eventually blocks the cell cycle in G1 through a p53‐ and p21‐dependent pathway (Wong et al, 2015; Fong et al, 2016; Lambrus et al, 2016; Meitinger et al, 2016; preprint: Meitinger et al, 2022)."
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"Conversely, USP28 silencing accelerated the cell cycle progression to G2/M phase."
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