IndraLab

Statements

USP1 decreases the amount of PCNA. 4 / 5
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"This decrease in USP1 activity allows PCNA ubiquitylation levels to increase and promote TLS [XREF_BIBR]."
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"Notably, exogenous expression of HA tagged C-SDE2 was able to antagonize the elevated PCNA-Ub levels caused by USP1 knockdown and UVC damage, suggesting that activated SDE2 regulates PCNA modification process independently of USP1 (XREF_FIG)."
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"The loss of USP1 activity increases the level of mono-ubiquitinated DNA clamp PCNA, impairing DNA repair."
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"USP1 knockdown or ML323 treatment reduced the expression of PCNA, cyclin D1 and cyclin E1, which meant that targeting USP1 could decrease the proliferation of HCC cells via cell cycle arrest.Nevertheless, there are several limitations to this study."
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