IndraLab

Statements

TBX18 activates HCN4. 4 / 4
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"Isl1 and Tbx18 are also potentially involved : both Isl1 and Tbx18 were significantly downregulated in the sinus node in heart failure and downregulation of Isl1 has been shown to downregulate HCN4 XREF_BIBR, XREF_BIBR and Tbx18 has been shown to upregulate HCN4 45; however, Tbx18 is a transcriptional repressor 63 and is unlikely to affect HCN4 directly."
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"Moreover, it could be shown that overexpression of Tbx18 in hiPSC induced upregulation of HCN4 and downregulation of Kir2.1 [24]."
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"In contrast, Tbx18 overexpression led to epigenetic activation of the HCN4 promoter (XREF_FIG), underlying heightened HCN4 function in Tbx18-NRVMs (XREF_FIG)."
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"Expectedly, Tbx18 caused upregulation (1.7-fold) of Hcn4, the molecular correlate of I that destabilizes the diastolic sarcolemmal membrane potential and confers the early (linear) rise of phase-4 diastolic depolarization."
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