IndraLab

Statements

USP2 activates CEBPA. 3 / 3
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"To validate that USP2 mediated the C/EBPα/ 11β-HSD1 pathway, we detected their expression in the liver of HFCS-drinking mice."
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"Collectively, our findings revealed the role of dietary fructose in MASLD pathogenesis and identified the USP2-mediated C/EBPalpha/ 11beta-HSD1 signaling as a potential target for the management of MASLD."
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"Our research indicates that fructose exposure leads to the upregulation of C/EBPα and 11β-HSD1, unveiling a mechanism by which USP2-mediated activation of C/EBPα and 11β-HSD1 is implicated in the onset and progression of MASLD.The liver is the central viscus for converting inactive cortisone into active cortisol via 11β-HSD132-34."
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