IndraLab

Statements

Cyclosporin A inhibits NLRP3. 5 / 5
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"Cyclosporin A (a cytochrome c inhibitor) could significantly inhibit NLRP3 inflammasome activation and mature IL-1beta secretion, while the ROS level was not influenced."
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"Cyclosporine A (CsA) strongly inhibits NLRP3 inflammasome activation, but this inhibition may be independent of its effects on cyclophilin D (CypD)-mediated MPT."
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"Cyclosporine A (CsA) strongly inhibits NLRP3 inflammasome activation, but this inhibition may be independent of its effects on cyclophilin D (CypD)-mediated MPT."
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"These results are similar to those caused by SMA/CORM2, which indirectly suggested SMA/CORM2 suppressed CsA-induced renal fibrosis through inhibiting the NLRP3 inflammasome dependent TGFβ/Smad signali[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"At the same time, western blot results showed that CsA and VBIT-4 treatment decreased the protein expressions of NLRP3 inflammasome-related (NLRP3, pro-IL-1β, and IL-1β p17) and cGAS-STING pathway-related (cGAS, STING, p-TBK1 , and p-IRF3 ) in sevoflurane-treated microglia (P<0.05 or P<0.001 vs. Sevo group, Figure 8B-Q)."
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