IndraLab

Statements

USP7 inhibits cellular senescence. 6 / 6
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"On the one hand, inhibition of USP7 increased tumor suppressor INK4a and caused senescence [50]."
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"We show that USP7 downregulation induces cellular senescence , arresting melanoma growth in vivo and proliferation in vitro in BRAF - and NRAS-mutant melanoma ."
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"Experimental results showed that USP7 overexpression suppressed the expression of several pathway-related genes, including Wnt, promoting cellular EMT and inhibiting cellular senescence and differentiation (128–130)."
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"In contrast, knockdown of USP7 with two independent shRNAs caused senescence in both the Leiden and control fibroblasts."
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"We can propose a scenario shared by melanomas with different genetic backgrounds and phenotypic features, where loss of USP7 induces p53- and p16-independent senescence through p21 upregulation and Cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36130505
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"Genetic and pharmacological inhibition of USP7 induces senescence in melanoma cells."
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