IndraLab

"223 Reduced USP18 expression results in increased antiviral activity against many viruses , such as SINV , hepatitis B virus and VSV , in USP18 knockout mice ."

"USP18 was shown to bind to IFNAR2 and attenuate the JAK-STAT pathway , thereby negatively regulating IFN signaling ( Table 1 ) .223 Reduced USP18 expression results in increased antiviral activity against many viruses , such as SINV , hepatitis B virus and VSV , in USP18 knockout mice.218 ,223,224,225 USP18 knockdown is concomitant with increased cellular protein ISGylation , prolonged STAT1 tyrosine phosphorylation and enhanced ISG expression , thus greatly enhancing the anti-HCV potency of IFN.226 All these studies suggest that USP18 disruption can impede its negative regulatory effect on IFN signaling , resulting in sustained JAK-STAT activity and antiviral activity ."