IndraLab

Statements

USP15 activates BMP. 7 / 7
| 7
reach
"In addition, USP15 also promotes TGF-beta and BMP signaling by opposing monoubiquitylation of R-SMADs, thereby allowing activated R-SMAD-SMAD4 complexes to recognize target promoters [XREF_BIBR]."
33335288
reach
"Here, our findings show that USP15 DUB activity is essential for BMP signalling, and that loss of USP15 function inhibits BMP signalling in human and mouse cells, as well as during Xenopus embryogenesis."
24850914
reach
"We therefore asked whether siRNA mediated knockdown of SMAD6 was also able to rescue the inhibition of BMP signalling caused by USP15 depletion."
24850914
reach
"Inhibition of USP15 might therefore be employed as a strategy to inhibit BMP signalling."
24850914
reach
"Furthermore, they found that USP15 modulates the BMP pathway during Xenopus embryogenesis (Herhaus et al., 2014)."
27155333
reach
"Although the mechanisms by which USP15 acts on TGFbeta and BMP signalling proposed in this study differ from those described above, the fundamental observations that USP15 enhances both TGFbeta and BMP signalling are consistent with studies described above XREF_BIBR."
25007997
reach
"In this study USP15 was found to potentiate both the TGF-beta pathway and the related BMP pathway by targeting mono-ubiquitinated R-SMADs for deubiquitination."
24756567