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Glyburide inhibits CASP1. 38 / 40
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"When THP-1 macrophages were incubated with TG in the presence of glyburide, treatment with glyburide decreased the activity of caspase-1 which is reported to induce the activity of caspase-3, -7, -8, and -9 (7) (Fig. 1E and 1F)."
33050989
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"Glyburide not only inhibited IL-1beta production and caspase-1 activation downstream of the P2X7 receptor, but was also effective against ATP-, nigericin- and IAPP induced inflammasome activation."
29515457
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"In addition, glyburide, an anti-diabetic drug that inhibits caspase-1 activation and IL-1beta secretion, may also serve as an effective inhibitor of NLRP3 formation following stress induced depression."
24850149
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"In this work, we found that glibenclamide could inhibit Nalp3 inflammasomes and Caspase-1 induced by LPS+ high glucose stimulation in cultured peritoneal macrophages, suggesting that the effects of glibenclamide on prevention of serum IL-1beta and TNF-alpha might be related to inhibiting Nalp3 inflammasomes and Caspase-1."
25077824
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"Glyburide also inhibits NLRP3, caspase-1, and IL-1β in macrophages and may be used as an inflammasome inhibitor to treat NLRP3-related inflammatory diseases [188]."
39710713
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"Glibenclamide decreases the protein and mRNA expression levels of NLRP3 and caspase-1 induced by OA."
31123394
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"Glibenclamide reversed ROS production and caspase-1 activity induced by HC diet."
39369873
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"Previously, we demonstrated that glyburide can block the activation of brain caspase-1 triggered by adenosine which is a key biologic in hypoxia induced anterograde amnesia."
27563288
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"Glyburide also inhibits caspase-1 activation and secretion of 1L-1β when studied against the stimuli which acts independently from P2X7 receptor [44]."
36006570
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"Glyburide inhibits LPS+ATP-induced caspase-1 activation, IL-1beta secretion, and macrophage death."
19805629
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"In a cyclophosphamide induced rat model of cystitis, glibenclamide treatment decreased caspase-1 activity along with levels of IL-1beta and IL-18 and subsequent bladder inflammation [XREF_BIBR]."
28740332
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"To determine whether caspase-1 activation is impaired by glyburide, LPS primed bone marrow derived macrophages (BMDMs) were incubated with glyburide for 15 min before ATP was added for another 30 min."
19805629
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"The LPS-induced caspase-1 activation observed in cIAP1 LysMcre Xiap −/− (and Xiap −/− ) BMDMs was driven by NLRP3 inflammasome signaling, as the NLRP3 inhibitors MCC950 or Glyburide blocked processing[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast to the related sulfonylurea glipizide, glyburide inhibited caspase-1 processing in a dose dependent fashion (XREF_FIG), and this prevented secretion of the caspase-1-dependent cytokines IL-1beta (XREF_FIG) and IL-18 (XREF_FIG)."
19805629
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"Inhibition of caspase-1 activation by glyburide was reversible because caspase-1 was activated if glyburide was removed from the culture medium before ATP addition."
19805629
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"In agreement with this, glibenclamide (Gly), a potassium channel inhibitor, blocked caspase 1 activation and IL-1beta release induced by UCN as well as IL-1beta release induced by Nd 2 O 3 and Y 2 O 3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27632706
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"These results demonstrate that the Cryopyrin inflammasome is essential for LPS+ATP-induced macrophage death and that glyburide inhibits LPS+ATP-induced caspase-1 activation, IL-1beta secretion, and macrophage death."
19805629
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"Glyburide reduced caspase-1 activity to levels not significantly different from the saline control."
27066297
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"Both caspase-1 activity in the urothelia and IL-1beta in the urine was prevented or attenuated by glyburide."
27066297
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"Glyburide effectively blocked caspase-1 activation and IL-1beta secretion by these stimuli too (XREF_FIG)."
19805629
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"The western blot analysis showed that 1microM MCC950 and 200microM glyburide significantly inhibited the activation of caspase-1 in to the cleaved form caspase-1 p10."
29872077
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"Glyburide (100 mumol/L) and Z-YVAD-FMK (2 mumol/L) did not completely inhibit caspase-1 cleavage, which is consistent with the literature."
22227418
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"Concurrently, glyburide inhibited caspase-1 activation by LPS+DOTAP (XREF_FIG), a stimulus that engages the Cryopyrin inflammasome independently of the P2X 7 receptor and pannexin-1."
19805629
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"To complement these experiments, we analyzed whether glyburide prevented caspase-1 activation in macrophages lacking ABC transporters or K ATP channels."
19805629
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"In agreement with the effects seen previously on IL-1beta secretion and caspase-1 activation glyburide and parthenolide did not inhibit AIM2 dependent ASC oligomerisation."
22216309
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"Glyburide prevented caspase-1 activity in both WT and Tnfrsf1a −/− macrophages primed with LPS and treated with compound A but, unlike alum treatment, glyburide did not completely prevent compound A-i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22365665
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"Our results indicated that glibenclamide suppressed NLRP3, caspase-1, and IL-1beta in mice spinal cord in morphine tolerance."
29178967
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"Additionally, glibenclamide inhibited NLRP3 and caspase-1 expression [XREF_BIBR]."
28740332
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"This enhancement of inflammasome activation by IAV in Ripk2 -/- BMDCs was dependent on NLRP3, as the NLRP3 specific inhibitor glyburide 32 significantly inhibited caspase-1 activation and IL-18 production (XREF_FIG)."
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"For inhibitor experiments, glyburide (100 mumol/L) and Z-YVAD-FMK (2 mumol/L) were added 30 minutes before PM 10 exposure to inhibit the NLRP3 inflammasome 38 or caspase-1, respectively."
22227418
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"Treatment with glyburide also reduced the activity of caspase-2, a known upstream molecule of caspase-1 (7), which increased upon TG treatment (Fig. 1G)."
33050989
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"Cai et al. reported that glyburide significantly inhibited high glucose plus LPS-induced elevation of NLRP3 and CASP1 proteins in peritoneal macrophages in vitro (37)."
35463001
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"Furthermore, we tested whether glibenclamide, a NLRP3 inflammasome inhibitor, can prevent the activation of both caspase-1 and caspase-3 induced by Tet-regulatable p210BCR-ABL expression in 32D/TetOff-p 210 cells."
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"Glibenclamide did not prevent the activation of both caspase-1 and caspase-3 (XREF_SUPPLEMENTARY)."
30167087
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"Furthermore, in in vitro studies, we found that glibenclamide inhibited caspase-1 activation and the maturation of IL-1beta induced by morphine and LPS in the presence of ATP."
29178967
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"Glombik et al [XREF_BIBR] observed that maternal diabetes causes the activation of NLRP3 inflammasome signaling by increasing the level of the NLRP3 protein subunit, and glyburide, as a NLRP3 inflammasome inhibitor, diminishes the level of NLRP3 protein and caspase-1 subunits, and has particular therapeutic value in anti- metabolic related inflammation."
33395071
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"One of the few studies in the murine model of cyclophosphamide (CP) induced cystitis, glyburide suggested to suppress caspase-1 with reduction in the release of IL-1beta; whereas NLRP3 inhibition blocks bladder dysfunction in CP model."
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"Glyburide had no effect on NLRP3, caspase-1 and IL-1beta expression as compared with the control group, while the NLRP3, caspase-1 and IL-1beta were decreased by (20.49 +/-7.6)% (t = 2.862, P < 0.01), (32.94 +/-3.44)% (t = 4.154, P < 0.001) and (24.67 +/-5.29)% (t = 2.335, P < 0.05) in the PDGF+ glyburide group, respectively, as compared with the PDGF group."
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