IndraLab

Statements

HNF1A binds CTNNB1 and LEF1. 7 / 7
| 7
sparser
"TCF1 and LEF1 can bind β-catenin and activate target genes when the Wnt pathway is active ( xref )."
24936456
sparser
"For instance, when ICAT, the inhibitor of β-catenin and TCF, which blocks the binding of β-catenin to TCF-1 and LEF-1, was over-expressed through retroviral transduction, thymocyte development was blocked at the DN to DP transition in FTOC assays, xref indicating an essential role for β-catenin/TCF-1 in the DN to DP transition during thymocyte development."
22321106
sparser
"Furthermore, overexpression of ICAT, which blocks the binding of β-catenin to TCF-1 and LEF-1, is known to result in a thymocyte development block at the DN to DP transition step in FTOC assays ( xref ), suggesting an essential role for β-catenin/TCF-1 in the DN to DP transition."
22535304
sparser
"However, activation of Ctnnb1 can also induce the expression of differentiation genes, such as , and , and the induction of these genes in mESCs mainly depends on the interactions of CTNNB1 with LEF1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943339
sparser
"Studies in vertebrates and Drosophila have led to a model in which Wnt signaling regulates an interaction between beta-catenin and POP-1-related proteins such as Tcf-1 or Lef-1."
9458047
sparser
"Both TCF1 and LEF1 interact with β-catenin to regulate the DP (CD4 + CD8 + ) cell differentiation into CD4 + T cells, and in this process, Th-POK is an upstream regulator."
31684152
sparser
"Activation of β-catenin can also induce the expression of differentiation genes and the induction of these genes in ESCs depends on the interaction of β-catenin with LEF1 and TCF1, two of the four LEF1/TCF family members ( xref ; xref )."
28288968