IndraLab

Statements

Hydroxychloroquine inhibits IFN-I. 4 / 4
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"Hydroxychloroquine reduces IFN-I production and improves the lipid profile, reducing LDL and insulin resistance [221]."
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"XREF_BIBR - XREF_BIBR Along those lines, hydroxychloroquine, documented to inhibit IFN-I production induced by lupus immune complexes in vitro, is now standard of care due to its demonstrated reduction of lupus flares."
25468480
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"The early blood IFN-I response was dependent on cGAS and was inhibited by hydroxychloroquine, which is consistent with our findings that aminoquinoline antimalarial drugs inhibit DNA activation of cGAS in vitro and in vivo XREF_BIBR, XREF_BIBR."
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"An existing drug, hydroxychloroquine (commercially known as Plaquenil), which efficiently perturbs the lysosomal function, strongly inhibits inflammatory responses, including the production of inflammatory cytokines and IFN-I (81)."
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