IndraLab

Statements

USP6 activates natural killer cell activation. 4 / 4
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"USP6 expression in Ewing sarcoma cells directly stimulates NK cell activation and degranulation in vitro, and functions by increasing surface levels of multiple NK cell-activating ligands."
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"Given the robust NK cell activation and paracrine feedforward loop induced by USP6 intratumorally, we speculated that USP6 might trigger systemic immune activation in vivo."
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"USP6 increases the surface levels of NK cell activation ligands, enhancing the interaction between NK cells and Ewing’s sarcoma cells, thus augmenting the tumor-killing capability of NK cells and highlighting the significance of USP6 in regulating the TME (Jain et al., 2023)."
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"Expression of USP6 in Ewing sarcoma cells directly induces NK cell activation by driving surface upregulation of NK-activating ligands."
37615015