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USP2 activates PPARGC1B. 2 / 2
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"Accordingly, an overexpression study using 293FT cells demonstrated that the introduction of USP2 increased the accumulation of Halo-tagged PGC1α in the nucleus (Figure 5C)."
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"Given that the protein levels of USP2 or C276A were comparable in USP2- and C276A-transfected cells, USP2 modulates PGC1α levels via ubiquitin isopeptidase activity.Finally, we examined whether USP2 directly digested the lysine48 (K48)-linked polyubiquitin chains on PGC1α, since K48-linked polyubiquitin chanins represent a canonical signal for proteasome degradation [41]."
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