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CTTN binds KCNA5. 4 / 4
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"Additionally, cortactin also interacted with the voltage-gated potassium channel Kv1.5 to control the N-cadherin-mediated increase in ion current across Kv1.5 channels [80] ."
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"In surviving Purkinje cells of infarcted heart zones that may initiate arrhythmias after myocardial infarction, cortactin dissociated from N-cadherin and instead associated with Kv1.5 [81] ."
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"In addition to showing the association of Kv1.5 with cortactin, Radice group used cardiac-specific N- cadherin conditional knockout mice to provide strong evidence for essential roles of N- cadherin in ICD integrity, cardiac conduction & rhythms, and I k,slow1 surface expression [ xref , xref – xref ]."
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"Thus, a dynamic balance of cortactin interactions with either N-cadherin or Kv1.5 may fine-tune ion potentials in cardiac cells with the potential to regulate arrhythmias.Cortactin colocalized with my[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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