IndraLab

Statements

BPS activates BAP1. 2 / 2
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"These results confirmed that the BPS construct efficiently induces genome edits in Bap1 and Pbrm1, but not in Setd2, in a dox-dependent manner.Upon confirming the genome editing we injected these ESCs into mouse blastocysts for tetraploid complementation and obtained nine founder BPS (Bap1-Pbrm1-Setd2) mice."
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"Collectively, these results demonstrate that the introduction of the BPS and ggt-tTA transgenes in the TRACK model induces a low frequency of somatic mutations in Bap1 and Pbrm1 in the kidneys and testes of these mice."
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