IndraLab
Statements
sparser
"Subsequently, we examined the biological activity of GST-JOSD2/JOSD1 by introducing their co-reported substrate proteins YAP xref , xref , as shown in Supplementary Fig. xref , both GST-JOSD2 and GST-JOSD1 efficiently removing the polyubiquitin chains of YAP, confirming that our purified recombinant protein are biologically active."
sparser
"More importantly, we performed in vitro deubiquitination assays using bacterial-expressed recombinant rhJOSD2 and found rhJOSD2 effectively removing the polyubiquitin chains of KRAS wild-type and mutants, while GST-JOSD1 failed to pose similar effects (Fig. xref and Supplementary Fig. xref )."