IndraLab

Statements

ATXN3 increases the amount of BAX. 5 / 6
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"In the present study, the involvement of p53 activation in mediating polyglutamine-expanded ataxin-3 upregulation of Bax expression was investigated by using cellular and animal models of SCA3.Cerebel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To confirm the involvement of p53-upregulated Bax expression in the pathogenesis of SCA3 neurodegeneration, SCA3 transgenic mice were used to test the possibility that polyglutamine-expanded ataxin-3 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These findings strongly suggest that polyglutamine-expanded ataxin-3 causes apoptotic neuronal death of pontine nuclei by upregulating Bax expression and activating caspase-9-mediated apoptotic pathwa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These findings underscore the efficacy of in vivo self-assembled mATXN3-siRNA in mitigating Purkinje cell apoptosis in YACMJD84.2 transgenic mice.Mutant ATXN3 has been found to upregulate Bax expression while downregulating Bcl-2 levels both in cellular and transgenic mouse models."
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"These results suggest that polyglutamine-expanded ataxin-3 upregulates Bax expression of cerebellum or pontine nuclei by enhancing p53 transcriptional activity.In addition to Bax, BH3-domain-only prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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