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USP15 decreases the amount of CD274. 6 / 6
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"On the one hand, as a key DUB of VGLL4, USP15 inhibits PD-L1 transcription by stabilizing VGLL4 and suppressing STAT3 activation."
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"Conversely, USP15 overexpression decreased mRNA and protein levels of PDL1 ( Fig. 4 f–j)."
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"For example, USP15-deficient T cells have been demonstrated to induce PD-L1 and CXCL2 expression through the production of IFN-γ and facilitate infiltration of T-bet + regulatory T cells and myeloid-derived suppressor cells (MDSCs), thus leading to tumor progression [75]."
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"Excessive IFN-γ production in USP15-deficient mice promotes expression of PD-L1 and CXCL12, causing accumulation of T -bet + regulatory T cells and CD11b + Gr-1 + myeloid-derived suppressor cells, the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To establish that USP15 suppresses PD-L1 expression through the VGLL4-STAT3 axis, VGLL4 was silenced in USP15 knocked down and overexpressed TNBC cells, nullifying the negative regulatory effect of US[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, the overexpression of USP15 was found to reverse the decrease in VGLL4 protein levels and the increase in p-STAT3 and PD-L1 protein levels induced by interference with SART3 ( Fig. 5 j-l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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