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Statements

E3_Ub_ligase binds BAP1 and BARD1. 3 / 3
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"According to this hypothesis, Nishikawa et al showed that BAP1 interacts with BARD1 to inhibit the E3 ligase activity of the BRCA1/BARD1 complex, and that BAP1 and BRCA1/BARD1 mutually regulate ubiquitination in the cell cycle and in the DNA damage response pathway. xref According to the present state of knowledge, it is reasonable to speculate that BAP1 may exert a regulatory role in the DNA damage response."
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"Here, we report that BAP1 interacts with BARD1 to inhibit the E3 ligase activity of BRCA1/BARD1."
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"They found that BAP1 did not appear to be involved in the deubiquitination of the BRCA1/BARD1 complex,29 and BAP1-mediated growth suppression in vitro was shown to be independent of wild-type BRCA1.4 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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