IndraLab

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Pioglitazone inhibits NLRP3. 6 / 6
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"Recently, pioglitazone, peroxisome proliferator activated receptor gamma (PPAR-gamma) agonist, reduced cerebral edema and immune response after traumatic brain injury by downregulating the effects of NLRP3 [XREF_BIBR]."
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"In addition, Guo et al [XREF_BIBR] found that the pioglitazone metformin complex preparation could reduce inflammation, inhibit activation of the NLRP3 inflammasome, and reduce the release of IL-1beta in the treatment of PCOS."
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"Pioglitazone decreased NLRP3 related brain edema and increased anaerobic glycolysis, resulting in the production of lactate in the ICH mice model."
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"Interestingly, pioglitazone reduced cerebral edema and immune response after TBI by downregulating the effects of NLRP3."
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"In summary, pioglitazone decreased NLRP3 related brain edema and increased anaerobic glycolysis, resulting in the production of lactate in an ICH mouse model."
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"Pioglitazone administration reduces NLRP3."
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