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Pioglitazone inhibits NLRP3. 13 / 13
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"Pioglitazone, an anti-diabetic drug, can suppress the microglial and astrocyte over-activations and decrease the mature form of IL-1β and caspase-1 via the downregulation of NLRP3 ( Yi et al., 2019 )."
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"In addition, Guo et al [XREF_BIBR] found that the pioglitazone metformin complex preparation could reduce inflammation, inhibit activation of the NLRP3 inflammasome, and reduce the release of IL-1beta in the treatment of PCOS."
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"This finding is supported by previous studies [48,49] , where the PPAR-γ agonist pioglitazone significantly inhibited NALP3 inflammasome and IL-1β induced by crystals of monosodium urate in HK-2 epith[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pioglitazone suppressed ethanol induction of NLRP3 in male mice and blocked ethanol suppression of IL-18 in both male and female mice in the hippocampus."
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"In summary, pioglitazone decreased NLRP3 related brain edema and increased anaerobic glycolysis, resulting in the production of lactate in an ICH mouse model."
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"Moreover, MgSO and pioglitazone inhibited the activation of the NLRP3 inflammasome (Figures 5E,F) in the hippocampus of CMS mice, which was consistent with the alleviation of hippocampal neuroinflammation and BBB damage mentioned above."
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"Pioglitazone decreased NLRP3 related brain edema and increased anaerobic glycolysis, resulting in the production of lactate in the ICH mice model."
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"Hong et al. demonstrated that the PPAR-γ agonist pioglitazone downregulated MSU crystal-induced NALP3 inflammasome activation and subsequently inhibited IL-1β production in HK-2 renal tubular cells [20]."
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"These results suggested that MgSO and pioglitazone may inhibit the activation of microglia by inhibiting NF-κB signaling and NLRP3 inflammasome to alleviate hippocampal neuroinflammation and repair BBB damage.3.5 MgSO 4 and pioglitazone alleviated the depressive-like behavior of CMS mice."
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"Interestingly, pioglitazone reduced cerebral edema and immune response after TBI by downregulating the effects of NLRP3."
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"Recently, pioglitazone, peroxisome proliferator activated receptor gamma (PPAR-gamma) agonist, reduced cerebral edema and immune response after traumatic brain injury by downregulating the effects of NLRP3 [XREF_BIBR]."
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"Pioglitazone administration reduces NLRP3."
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"These results suggest that treatment with MgSO and pioglitazone effectively inhibits hippocampal neuroinflammation in CMS mice.3.4 MgSO 4 and pioglitazone inhibit microglial activation via IKK/NF-kB and NLRP3 inflammasome signaling pathways."
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