IndraLab

Statements

BAP1 activates transcription, DNA-templated. 12 / 12
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"As a deubiquitinating enzyme, BAP1 contributes to gene transcription, cell differentiation, DNA damage repair, apoptosis, and cell metabolism in tumor inhibition."
32944533
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"In addition, melanoma specific network analysis followed by Kaplan-Meier analysis along with log-rank tests identified tyrosinase, hedgehog acyltransferase, BRCA1 associated protein 1 and melanocyte inducing transcription factor as potential therapeutic targets for melanoma."
31289481
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"These included the SETD1A, KMT2C and MLL3, KMT2E and MLL5, and KMT2A and MLL1 methyltransferases that install activating histone H3-lysine 4 trimethylation (H3K4me3) marks; OGT (O-GlcNac transferase), a protein that modulates multiple cell pathways but more recently has been implicated in promoting promoter occupancy of RNAPII; and BAP1 (BRCA1 Associated Protein 1), a deubiquitinase that stimulates transcription, at least in part, by removing repressive histone H2A-K119 monoubiquitin."
28407486
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"These data indicate that BaP1 triggers transcription mechanisms in FLSs that result in an increase in COX-2 protein content."
32094439
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"The observation that BaP1 induced translocation of the NF-κB p50 and RelA (p65) subunits into the nucleus gives further support to the hypothesis that this transcription factor is activated by BaP1 and provides a mechanism for this activation."
32094439
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"p53 binds to the SLC7A11 promoter, directly suppressing its transcription; the nuclear deubiquitinase (DUB) BAP1 represses SLC7A11 transcription by removing histone 2A ubiquitination from the SLC7A11 promoter; and KEAP1 represses SLC7A11 transcription through degrading NRF2, a master transcription factor of antioxidant response and regulator of SLC7A11."
30987975
eidos
"Taken together , these results establish that PRC1 is epistatic to BAP1.com and that BAP1 promotes transcription by counteracting PRC1-mediated H2A ubiquitination ( Fig. 7 ) ."
30664650
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"Previously, we found that hypoxia-inducible factor 2α (HIF2α) and BAP1 activate interferon-stimulated gene factor 3 (ISGF3), a transcription factor activated by type I interferons and a tumor suppressor in ccRCC xenograft models."
35995140
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"BAP1 activates transcription in an enzymatic-activity-dependent manner and regulates the expression of a variety of genes involved in numerous cellular processes."
20805357
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"RNA sequencing and chromatin immunoprecipitation coupled with quantitative PCR analyses revealed that reduced BAP1 expression suppressed upregulation of the transcription factors AP-1 and EGR1/2, as well as myeloid dysplasia associated genes, by retarding H2AK119Ub removal caused by ASXL1 mutation."
34186160
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"BAP1 complex promotes transcription by opposing PRC1 mediated H2A ubiquitylation."
30664650
sparser
"BAP1 activates transcription in an enzymatic-activity-dependent manner and regulates the expression of a variety of genes involved in numerous cellular processes."
20805357