IndraLab

Statements

BAP1 activates DNA-templated transcription. 16 / 16
| 1 14 1
reach
"These included the SETD1A, KMT2C and MLL3, KMT2E and MLL5, and KMT2A and MLL1 methyltransferases that install activating histone H3-lysine 4 trimethylation (H3K4me3) marks; OGT (O-GlcNac transferase), a protein that modulates multiple cell pathways but more recently has been implicated in promoting promoter occupancy of RNAPII; and BAP1 (BRCA1 Associated Protein 1), a deubiquitinase that stimulates transcription, at least in part, by removing repressive histone H2A-K119 monoubiquitin."
28407486
reach
"As a deubiquitinating enzyme, BAP1 contributes to gene transcription, cell differentiation, DNA damage repair, apoptosis, and cell metabolism in tumor inhibition."
32944533
eidos
"Taken together , these results establish that PRC1 is epistatic to BAP1.com and that BAP1 promotes transcription by counteracting PRC1-mediated H2A ubiquitination ( Fig. 7 ) ."
30664650
reach
"For example, one study showed that BAP1 promotes the development of breast cancer by enhancing the stability of the transcription factor KLF5 (30)."
36003792
reach
"p53 binds to the SLC7A11 promoter, directly suppressing its transcription; the nuclear deubiquitinase (DUB) BAP1 represses SLC7A11 transcription by removing histone 2A ubiquitination from the SLC7A11 promoter; and KEAP1 represses SLC7A11 transcription through degrading NRF2, a master transcription factor of antioxidant response and regulator of SLC7A11."
30987975
reach
"Previously, we found that hypoxia-inducible factor 2α (HIF2α) and BAP1 activate interferon-stimulated gene factor 3 (ISGF3), a transcription factor activated by type I interferons and a tumor suppressor in ccRCC xenograft models."
35995140
reach
"BAP1 complex promotes transcription by opposing PRC1 mediated H2A ubiquitylation."
30664650
reach
"Using RNAi, we found that certain deubiquitinases, BAP1, USP14 and OTUD5 each promote proviral transcription."
37523412
reach
"Luchini et al. also reported that BAP1 mutated clear cell renal carcinomas were frequently observed in females and were associated with high tumor grade (p < 0.0001), increased all-cause mortality, cancer-specific mortality, and risk of recurrence.NCOR1P1, Nuclear Receptor Corepressor 1 Pseudogene 1, is predicted to enable transcription corepressor activity, and to be involved in the negative regulation of transcription by RNA polymerase II ."
38982123
reach
"Additionally, BAP1 modulates transcription, DNA repair, and replication by regulating chromatin remodeling via histone H2AK119 deubiquitination (12)."
37964637
reach
"These data indicate that BaP1 triggers transcription mechanisms in FLSs that result in an increase in COX-2 protein content."
32094439
reach
"BAP1 activates transcription in an enzymatic-activity-dependent manner and regulates the expression of a variety of genes involved in numerous cellular processes."
20805357
reach
"It is expected that BAP1 promotes tumorigenesis of CCA by modulating DNA repair, gene transcription, and post-translational modification, such as glycosylation."
26100596
reach
"The observation that BaP1 induced translocation of the NF-κB p50 and RelA (p65) subunits into the nucleus gives further support to the hypothesis that this transcription factor is activated by BaP1 and provides a mechanism for this activation."
32094439
sparser
"BAP1 activates transcription in an enzymatic-activity-dependent manner and regulates the expression of a variety of genes involved in numerous cellular processes."
20805357
reach
"In addition, melanoma specific network analysis followed by Kaplan-Meier analysis along with log-rank tests identified tyrosinase, hedgehog acyltransferase, BRCA1 associated protein 1 and melanocyte inducing transcription factor as potential therapeutic targets for melanoma."
31289481